![]() ![]() ![]() Both solutions were diluted 10 times with the same buffer and their absorbance was read at 510 nm using spectrophotometer (PerkinElmer, USA). For this, two 1-g samples of dried extract were dissolved in 10 mL of buffer solution with pH = 1 composed of 125 mL of KCl 0.2 M (Merck, Germany) and 375 mL of HCl 0.2 M (Merck, Germany) and 10 mL of buffer solution with pH = 4.5 composed of 400 mL of sodium acetate 1 M (Merck, Germany), 240 mL of HCl 1 M, and 360 mL of water, respectively. The obtained extract was standardized based on the total anthocyanin content using the pH differential method. The extract was then filtrated and concentrated using rotary evaporator (Heidolph, Germany). The obtained material was then extracted by maceration with ethanol 70% (Stalk, Iran) repeated for 3 times. After washing and separation of the cores, the fruits were crushed by electric mixer (Moulinex, France) and filtrated by filter paper. mas were collected from the forests of Ghazvin, Iran, in July 2012. Plant Material and Extractionįresh ripe berries of C. fruit extract on several markers of glycemic control in type 2 diabetic adult patients. Therefore, this trial aimed to evaluate the effects of Cornus mas L. Although this plant is traditionally used as an antidiabetic supplement, there is no clinical study about its effect. fruit on reduction of blood glucose level in diabetic rats. Furthermore, a recent animal study has shown the effect of Cornus mas L. It has been shown that anthocyanins increase insulin secretion from pancreatic β-cells and improve insulin resistance. The fruits (berries) of this plant are rich in anthocyanins including delphinidin-3-glucoside, cyanidin-3-rhamnoglucoside, cyanidin-3-glucoside, cyanidin-3-galactoside, and pelargonidin-3-galactoside. ![]() (cornelian cherry) is a plant found in parts of central and southern Europe as well as western Asia including northern forests of Iran. Medical nutrition therapy is recommended for all patients with DM and, along with activity, is a cornerstone of treatment. Also, aggressive management of cardiovascular risk factors, including dyslipidemia, is needed to reduce the likelihood of development of macrovascular disease. Optimal management of the patient with DM will reduce or prevent complications and improve quality of life. DM is the leading cause of blindness in adults aged 20 to 74 years and end-stage renal disease (ESRD) and a main cause of cardiovascular events. Type 2 DM, characterized by insulin resistance and a relative lack of insulin secretion, accounts for as much as 90% of all cases of DM and its prevalence is increasing. Introductionĭiabetes mellitus (DM) is one of the most common endocrine disorders characterized by hyperglycemia. improves glycemic control by increasing insulin level and reduces TG serum level in type 2 diabetic adult patients. Daily consumption of the fruit extract of Cornus mas L. After 6 weeks of intervention, significant increase in insulin level (1.13 ± 1.90 versus −0.643 ± 1.82, ) as well as decrease in (−0.24 ± 0.429 versus 0.023 ± 0.225, ) and TG (−23.66 ± 55.40 versus 2.83 ± 15.71, ) levels was observed in drug group compared to placebo. Fasting plasma levels of glucose, insulin,, and triglyceride as well as 2-hour postprandial glucose level (2Hpp) were measured before and after the intervention and finally the mean values were compared between groups. Each drug capsule contained 150 mg of anthocyanins. Sixty patients with type 2 diabetes were randomly assigned to two groups to receive either the extract or placebo capsules (2 capsules twice daily) for 6 weeks. In this study, we evaluated the effects of the fruit extract of this plant on biomarkers of glycemic control in adult patients with type 2 diabetes. (cornelian cherry) is traditionally used as an antidiabetic supplement however, there is no related clinical trial. ![]()
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